Side Effects
of Carbidopa
Please contact us for medical advice regarding side effects stemming from the drug carbidopa.

Carbidopa Side Effects

WARNINGS --- LODOSYN (Carbidopa) has no antiparkinsonian effect

Carbidopa Ineffective

Sometimes the side effects caused by the drug carbidopa are ignored in the face of Parkinson’s disease symptom collapse. As discussed on other carbidopa pages of this website, carbidopa irreversibly binds to vitamin B6 and B6-dependent enzymes causing nutritional depletion. One of these B6-dependent enzymes is AADC which is responsible for dopamine synthesis. If carbidopa induces significant B6 depletion, the associated compromised in dopamine synthesis will cause dopamine concentrations to deplete throughout the body. Depletion of dopamine by carbidopa can cause a relative nutritional deficiency of vitamin B6 whose symptoms are identical to Parkinson’s disease symptoms getting worse. “The Baker Study” webpage on this website discusses how vitamin B6 deficiency symptoms may be identical to Parkinson’s disease symptoms. Below is a listing of carbidopa side effects. Just as discussed in “The Baker Study” webpage, the highlighted carbidopa side effects could be from Parkinson’s disease symptoms or dopamine depletion secondary to carbidopa depleting vitamin B6.

Side effects and adverse reactions associated with carbidopa (The bold carbidopa side effects may also be symptoms of Parkinson’s disease getting worse):

  • Glossitis
  • Leg Pain
  • Ataxia
  • Falling
  • Gait Abnormalities
  • Bhepharospasm (which may be taken as an early sign of excess dosage)
  • Trismus
  • Increased Tremor
  • Numbness
  • Muscle Twitching
  • Peripheral Neuropathy
  • Myocardial Infarction
  • Flushing
  • Oculogyric Crises
  • Diplopia
  • Blurred Vision
  • Dilated Pupils
  • Urinary Retention
  • Urinary Incontinence
  • Dark Urine
  • Hoarseness
  • Malaise
  • Hot Flashes
  • Sense of Stimulation
  • Dyspepsia
  • Constipation
  • Palpitation
  • Dyskinesias
  • Sleep without warning
  • Drowsiness
  • Fever
  • Hyperthermia
  • Muscle rigidity
  • Involuntary movements
  • Altered consciousness
  • Mental status changes
  • Autonomic dysfunction
  • Tachycardia
  • Hypertension
  • Fatigue
  • Upper Respiratory Infection
  • Bruxism
  • Hiccups
  • Common Cold
  • Diarrhea
  • Urinary Tract Infections
  • Urinary Frequency
  • Flatulence
  • Priapism
  • Pharyngeal Pain
  • Abdominal Pain
  • Bizarre Breathing Patterns
  • Burning Sensation of Tongue
  • Back Pain
  • Shoulder Pain
  • Chest Pain (noncardiac)
  • Muscle Cramps
  • Paresthesia
  • Increased Sweating
  • Syncope
  • Orthostatic Hypotension
  • Asthenia (weakness)
  • Dysphagia
  • Horner's Syndrome mydriasis
  • Dry Mouth
  • Sialorrhea
  • Neuroleptic Malignant Syndrome
  • Myoglobinuria
  • Increased serum myoglobin
  • Urge to gamble
  • Increased sexual urges
  • Urge to spend money
  • Binge eating
  • Hallucinations
  • Psychotic-like behavior
  • Paranoid ideation
  • Delusions
  • Confusion
  • Phlebitis
  • Hemolytic and Nonhemolytic Anemia
  • Rash
  • Gastrointestinal Bleeding
  • Duodenal Ulcer
  • Henoch-Schonlein Purpura
  • Decreased Hemoglobin and Hematocrit
  • Thrombocytopenia
  • Leukopenia
  • Angioedema
  • Urticaria
  • Pruitus
  • Alopecia
  • Dark Sweat
  • Abnormalities in Alkaline
  • Phosphatase 
  • Abnormalities in:
    • SGOT (AST)
    • SGPT (ALT)
  • Abnormal Coombs' Test
  • Abnormal Uric Acid
  • Hypokalemia
  • Abnormalities in Blood Urea Nitrogen
  • Increased Creatinine
  • Increased Serum
  • LDH
  • Glycosuria
  • Psychotic-like behavior
  • Disorientation
  • Aggressive behavior
  • Agitation
  • Delirium
  • Depression
  • Suicidal ideation
  • Dark color saliva
  • Dark color urine
  • Dark color sweat
  • Elevated bilirubin
  • Leukocytosis


Source:

  • International Journal of General Medicine 2011:4 165–174
  • International Journal of General Medicine 2012:5 413–430
  • The drug, Healthcare and Patient Safety 2014:6 93–99
  • Clinical Pharmacology: Advances and Applications 2014:6 161–169
  • Lodosyn (carbidopa) prescribing information approved by the FDA

For more information on our approach to Parkinson’s disease send an email to info@parkinsonsclinics.com or call 218-626-2220. After you send your email, we may ask for more information. All communications will be kept confidential. If you have any questions, please call us free of charge.

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